EXPLORING THE INTERSECTION OF EPIGENETICS, DNA REPAIR, AND IMMUNOLOGY FROM STUDIES OF ICF SYNDROME, AN INBORN ERROR OF IMMUNITY

Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a rare autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability accompanied by DNA hypomethylation.Pathological variants in the DNMT3B, ZBTB24, CDCA7, or HELLS genes underlie its etiology.Activated lymphocytes from patients often display

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South Africa, Sweden, and Good International Citizenship

There are those who argue that a state embodying good international citizenship (GIC) must actively seek to improve the world around it, thereby making a positive contribution to overcoming global challenges.A good international citizen (state) must also be a sound anchor adj2 proponent of multilateral cooperation, usually manifesting in global pla

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